Osteogenic sarcoma producing human chorionic gonadotrophin: Case report with immunohistochemical studies

Abstract

An osteogenic sarcoma occurring in a 22‐year‐old woman was found to be associated with production of a large amount of beta human chorionic gonadotrophin (B‐hCG). Pregnancy was excluded on the basis of a normal ultrasonogram and a proliferative type endometrium obtained by curettage. A homogenate of the tumor was strongly positive for B‐hCG while immunohistochemical staining of the tumor cells was strongly positive for B‐hCG and negative for pregnancy associated glycoprotein. These results indicate ectopic production of hCG by the osteosarcoma. Copyright © 1984 American Cancer Society