Adenoviruses in Gene Therapy- A Review

Abstract

Viruses have become extensively studied over the decade not just for decoding their complex structures but also to understand disease pathways and for the treatment of various diseases as well. The advent of recombinant technology has allowed viruses to be used as vectors in gene therapy, which is the treating of diseases by inserting/deleting genes. One such virus which has risen to prominence because of its flexibility in terms of usage and its versatility in regard to organisms is the adenovirus. This review will elaborate the remarkable progress that has been made with these vectors in the past decade, shortcomings involved in the entire process as well as current biological strategies employed in utilizing adenovirus mediated gene therapy.