Preterm birth is a significant perinatal problem contributing to perinatal morbidity and mortality. Heavy vaginal ureaplasma colonisation is suspected of playing a role in preterm birth and preterm rupture of the membranes. Antibiotics are used to treat infections and have been used to treat pregnant women with preterm prelabour rupture of the membranes, resulting in some short-term improvements. However, the benefit of using antibiotics in early pregnancy to treat heavy vaginal colonisation is unclear.
Raynes-Greenow, C. H., Roberts, C. L., Bell, J. C., Peat, B., Gilbert, G. L., & Parker, S. (2011). Antibiotics for ureaplasma in the vagina in pregnancy. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd003767.pub3