The combined effects of dosage level and interstimulus interval on the formation of one-trial poison-based aversions in rats

Abstract

Adult male rats were allowed to drink a novel solution of sodium saccharin which was followed .5, 1.5, 4.5, 7.0, 13.5, or 24.0 h later by intubation of a .9, 2.7, 8.1, or 12.15% (w/v) solution of sodium chloride (NaCl). Three days after the single training trial, consumption of saccharin was again measured. Significant differences between groups were found. When consumption by the experimental groups at each CS-UCS delay was compared with that of the isotonic NaCl (.9%) control group, it was found that all groups showed aversions at delays of .5, 1.5, and 4.5 h. Animals intubated with 8.1% or 12.15% NaCl solution also showed aversions at a delay of 7.0 h, and those intubated with the 12.15% solution showed an aversion at a delay of 13.5 h. No NaCl concentration used produced aversions at a CS-UCS interval of 24.0. These results reflect differences in the effectiveness of a range of NaCl concentrations in producing one-trial aversions at long CS-UCS intervals. © 1975 Psychonomic Society, Inc.