Inhibition of Sardine Flesh Lipoxygenase by a New Antioxidant from Aspergillus terreus.

Abstract

A new antioxidant and potent lipoxygenase (LOX) inhibitor, NC3B, was isolated from the fungus Aspergillus terreus and identified a 1,3-dihydro-7-methyl-4,5,6-trihydroxy-isobenzofuran. Under wt. gain method conditions with Me linoleate as a substrate, NC3B was a stronger antioxidant than tocopherol (Toc) and acted as a weak Toc synergist during the autoxidn. of Me linoleate. NC3B significantly inhibited the oxidn. of linoleic acid by sardine flesh LOX and caused redn. in oxygen uptake by the substrate. [on SciFinder(R)]