Enhancement of the enzymatic activity of activated coagulation factor IX by anti-factor IX antibodies

  • SCHEIFLINGER F
  • DOCKAL M
  • ROSING J
  • et al.
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Abstract

Factor VIIIa (FVIIIa) binds to activated FIX and enhances the activation of FX by several orders of magnitude. Deficiency of FVIII causes the bleeding disorder hemophilia A and is treated by i.v. infusion of FVIII concentrates.

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SCHEIFLINGER, F., DOCKAL, M., ROSING, J., & KERSCHBAUMER, R. J. (2008). Enhancement of the enzymatic activity of activated coagulation factor IX by anti-factor IX antibodies. Journal of Thrombosis and Haemostasis, 6(2), 315–322. https://doi.org/10.1111/j.1538-7836.2007.02868.x

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