Factor VIIIa (FVIIIa) binds to activated FIX and enhances the activation of FX by several orders of magnitude. Deficiency of FVIII causes the bleeding disorder hemophilia A and is treated by i.v. infusion of FVIII concentrates.
CITATION STYLE
SCHEIFLINGER, F., DOCKAL, M., ROSING, J., & KERSCHBAUMER, R. J. (2008). Enhancement of the enzymatic activity of activated coagulation factor IX by anti-factor IX antibodies. Journal of Thrombosis and Haemostasis, 6(2), 315–322. https://doi.org/10.1111/j.1538-7836.2007.02868.x
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