Design, Synthesis and Biological Screening of New Benzimidazole Derivatives

Abstract

In this study, we synthesized a series of benzimidazole compounds containing. 1,3,4-thiadiazole ring from many reaction steps. The obtained benzimidazole series were characterized by melting point, Data from FT-IR and 1H-13C-NMR and In vitro screening of antibacterial activity against strains of selected pathogenic Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Acinetobacter baumannii, Pseudomonas aeruginosa) bacteria relative to (Amoxicillin) and (Ciprofloxacin) as standard antibacterial agents has shown high pharmacological activity.