Production of LLU-α following an oral administration of χ-tocotrienol or χ-tocopherol to rats

Abstract

An oral administration of χ-tocotrienol (χ-T3) or χ-tocopherol (χ-Toc) to male rats caused an increase of the concentration of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxy chroman (LLU-α, χ-CEHC), a natriuretic compound, in plasma with a T(m)(a)(x) of 9 h. The configuration at C-2 of LLU-α produced from χ-T3 or χ-Toc was assigned as S-form by an HPLC equipped with a chiral column. These data indicated that LLU-α was produced not only from χ-Toc but also χ-T3, without racemization at C-2 in rats.