One-pot synthesis of 5-(substituted-amino)pyrazoles

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Abstract

An efficient and mild one-pot synthesis of substituted 5-alkylamino and/or 5-(arylamino)pyrazoles is described. A suitably decorated β-ketoamide, an aryl or alkyl hydrazine and Lawesson's reagent are suspended in THF/Py and gently heated to yield the requisite 5-aminopyrazoles. © 2004 Elsevier Ltd. All rights reserved.

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Dodd, D. S., & Martinez, R. L. (2004). One-pot synthesis of 5-(substituted-amino)pyrazoles. Tetrahedron Letters, 45(22), 4265–4267. https://doi.org/10.1016/j.tetlet.2004.04.017

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