Ang2, the instigator of inflammation

Abstract

In this issue of Blood, Scholz et al. have demonstrated that the expression of angiopoietin-2 (Ang2) in the endothelial cells is sufficient to recruit myeloid cells and induce inflammation even in the absence of preceding proinflammatory stimuli.1 This finding shows that the endothelial cells are capable of leading and orchestrating the whole inflammatory process via Ang2.