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A novel RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group.

Nucleic acids symposium series (2004) (2006) (50) 11-12
DOI: 10.1093/nass/nrl006
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Abstract

A novel method for the synthesis of RNA oligomers with 2-cyanoethoxymethyl (CEM) as the 2'-hydroxyl protecting group has been developed. The new method allows the synthesis of oligonucleotides with an efficiency and final purity comparable to that obtained in DNA synthesis.(1) In addition, the CEM method has the potential for application to the synthesis of very long RNA oligonucleotides.

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APA

Shiba, Y., Kitagawa, H., Masutomi, Y., Ishiyama, K., Ohgi, T., & Yano, J. (2006). A novel RNA synthetic method with a 2’-O-(2-cyanoethoxymethyl) protecting group. Nucleic Acids Symposium Series (2004), (50), 11–12. https://doi.org/10.1093/nass/nrl006

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