Getting the genome in shape: The formation of loops, domains and compartments

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Abstract

The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

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Bouwman, B. A. M., & de Laat, W. (2015, August 10). Getting the genome in shape: The formation of loops, domains and compartments. Genome Biology. BioMed Central Ltd. https://doi.org/10.1186/s13059-015-0730-1

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