Abstract
Gluconeogenesis from [1‐14C]pyruvate in the perfused liver from fasted rats was stimulated by oleic acid as indicated by an increase in medium glucose, liver glycogen and specific activity of medium [14C]glucose. A balance of carbon from pyruvate revealed that in the presence of oleic acid 2 moles of pyruvate were utilized for each mole of glucose synthesized in contrast to a ratio 4:1 without fatty acid. From this and 14CO2 data it is concluded that oleic acid inhibited pyruvate oxidation markedly. Glucagon increased glucose formation from pyruvate but not from glycerol. Copyright © 1967, Wiley Blackwell. All rights reserved
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CITATION STYLE
Teufel, H., Menahan, L. A., Shipp, J. C., Böning, S., & Wieland, O. (1967). Effect of Oleic Acid on the Oxidation and Gluconeogenesis from [1‐14C]Pyruvate in the Perfused Rat Liver. European Journal of Biochemistry, 2(2), 182–186. https://doi.org/10.1111/j.1432-1033.1967.tb00124.x
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