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Synthesis and structural investigations of a a-hydroxylated b-hexapeptide

  • Gessier F
  • Rueping M
  • Seebach D
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(2S,3S)-a-Hydroxy-b3-Hleu, -b3-HAla and -b3-HVal-amino acids were prepd. and used for the synthesis of a b-hexapeptide. The resulting a-hydroxylated-b3-hexapeptide (terminally protected) and its fully deprotected form are insol. in most org. solvents including MeOH and fluorinated alcs., suggesting that they form aggregates or that they adopt a sheet-like conformation. Their phys. properties prevented any CD spectroscopic investigations and limited the possibilities of NMR spectroscopy. [on SciFinder (R)]




Gessier, F., Rueping, M., & Seebach, D. (2002). Synthesis and structural investigations of a a-hydroxylated b-hexapeptide. Peptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002.

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