Maturation Of Stem Cell-Derived Cardiomyocytes: Foe In Translation Medicine

Abstract

With the in-depth study of heart development, many human cardiomyocytes (CMs) have been generated in a laboratoryenvironment. CMs derived from pluripotent stem cells (PSCs) have been widely used for a series of applications suchas laboratory studies, drug toxicology screening, cardiac disease models, and as an unlimited resource for cell-basedcardiac regeneration therapy. However, the low maturity of the induced CMs significantly impedes their applicability.Scientists have been committed to improving the maturation of CMs to achieve the purpose of heart regenerationin the past decades. In this review, we take CMs maturation as the main object of discussion, describe the characteristicsof CMs maturation, summarize the key regulatory mechanism of regulating maturation and address the approachesto promote CMs maturation. The maturation of CM is gradually improving due to the incorporation of advanced technologiesand is expected to continue