Comprehensive Review on Recent Developments in the Diagnostics and Vaccines against Peste des Petits Ruminants

Abstract

Peste des petits ruminants (PPR), a viral disease of goats and sheep caused by a morbilli- ment of PPR eradication by 2030 has opened lot of research gaps for the development of vaccines heterologous systems across the globe for development of vaccines and/or diagnostic antigens. The DNA technology, recombinant protein based vaccines and/or diagnostics are being tested in various and diagnostics for differentiating infected and vaccinated animals. With the advent of recombinant peptides, reverse genetics, anti idiotypic antibody based vaccines and helper cell dependent diag- nant viral vectored vaccines, RNA interference as a therapy, suicidal DNAs, synthetic epitopes and recombinant viral proteins, virus like particle based vaccines, bivalent/multivalent vaccines, recombi- nostics represent the present vaccine/diagnostic development strategies for the effective control and ment of diagnostics and vaccines against PPR.