The role of complex metabolic antihypoxants in the treatment of acute drug poisoning in children

Abstract

Critical health conditions of children, including acute poisoning, are accompanied by the development of organ dysfunctions, particularly acute kidney injury (AKI). Objective. To study the efficiency of complex metabolic antihypoxant cytoflavin in the treatment regimen for severe acute drug poisoning in children. Patients and methods. The results of observation of 52 patients aged 15–18 admitted to the Toxicology Unit of the City Children’s Hospital named after N.F. Filatov are presented. The children were divided into two groups: the main group (i, n = 27), where cytoflavin was added to the treatment (intravenously, 20.0 ml per day diluted with 200.0 ml of 5% glucose solution at a rate of 3–4 ml/min, a course of 5–7 days), and the control group (II, n = 25), which was provided with standard treatment. The general condition and dynamics of laboratory indicators were evaluated for all patients (1st, 5th and 7th day of the disease). Results. It was revealed that 24–48 hours after admission to hospital, in 100% of cases, AKI with different severity levels developed, accompanied by azotemia. In 92% of adolescents, during the first night, urine syndrome with the predominance of proteinuria was detected, and in 22.8% – glycosuria. The inclusion of cytoflavin in therapy accelerated the normalization of serum creatinine level and significantly reduced the length of stay in the intensive care unit and in the hospital in general (on average 7.5 against 10.7 bed-days). Conclusion. The results obtained testify to the effectiveness of cytoflavin in the treatment of severe forms of acute drug poisoning with AKI in children.