Analogs of biologically active compounds IX.1 Synthesis of several new uracil and pteridine 6-azaanalogs based on cyclization of arylhydrazones derived from mesoxalic acid

Abstract

A series of 5C and 5N substituted 3-oxo-2-phenyl-1,2,4-triazine-6-carbonitriles and 8-imino-2-arylpyrimido[4,5-e][1,2,4]triazine-3,6(2H,5H)-diones (6-aryl-6-azapteridines) are described via a cyclocondensation reaction from the corresponding aryliminohydrazones with CDI. The required aryliminohydrazones were obtained from the starting compound – malononitrile. These prepared compounds were tested for cytotoxic activity on cancer cell lines.