Rapid-kilovoltage-switching dual-energy computed tomography (CT) for differentiating spinal osteolytic metastases from spinal infections

Abstract

Background: Rapid-kilovoltage-switching dual-energy computed tomography (RDECT) is a non-invasive, alternative technique for quantitative diagnosis. This study aimed to investigate the value of RDECT for differentiating spinal osteolytic metastases (SOM) from spinal infections (SIs). Methods: RDECT was performed on 29 patients with SOM and 18 patients with SIs. Both iodine-based and water-based material decomposition images were generated from the spectral CT scan. The iodine/ water densities of lesions on iodine/water material-decomposition images and the CT attenuation values on traditional CT images were measured three times at different image levels, and the averages were calculated. The lesion-to-muscle ratio (LMR) and lesion-to-artery ratio (LAR) for iodine density measurements were calculated. All parameters were compared between the two groups using the two-tailed Student's t-test. A P value <0.05 was considered statistically significant. The sensitivity and specificity for differentiating SOM from SIs were determined using receiver operating characteristic curves (ROC). Results: Iodine density, LMR, and LAR during the arterial phase (AP) and venous phase (VP) were all significantly higher for SOM than for SIs (all P<0.05). The water densities and traditional CT attenuation values during the AP and VP were not significantly different between the two groups. For ROC analysis, LAR during the VP (LARVP) showed the best diagnostic performance, with an area under the ROC curve (AUC) value of 0.862. When the LARVP was 0.54, the sensitivity was 82.80% and the specificity was 77.80% for differentiating SOM from SIs. Conclusions: RDECT can provide additional information that may be useful for differentiating atypical SOM from SIs.