FVIII stabilization: VWF D′D3 will do

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Abstract

In this issue of Blood, Yee et al1 have demonstrated that expression or infusion of a truncated von Willebrand factor (VWF) fragment containing the factor VIII (FVIII)-binding D′D3 region of VWF is sufficient to stabilize endogenous FVIII levels in VWF-deficient mice. In the absence of the carrier function of VWF, FVIII is susceptible to rapid proteolysis and clearance resulting in markedly reduced plasma levels of FVIII that contribute to a bleeding diathesis. © 2014 by The American Society of Hematology.

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Swystun, L. L., & Lillicrap, D. (2014, July 17). FVIII stabilization: VWF D′D3 will do. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2014-06-578955

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