In vitro quality evaluation of amoxicillin trihydrate capsules marketed in gaza strip-palestine

Abstract

The objective of this Post-Marketing Pharmaceutical Quality Evaluation of Amoxi-cillin trihydrate 500mg capsules to evaluate the quality standards of seven different marketed brands with various price ranges, collected from retail drug stores of Gaza-strip, Palestine. The quality of amoxicillin trihydrate capsules was assessed through evaluation of identification, uniformity of weight, disintegration, dissolution and assay of content of active ingredient using spectrophotometric method. It was observed that six of seven brands of amoxicillin trihydrate capsules meet quality specifications in Pharmacopoeia. The spectrophotometric method which used in assay of content of active ingredient of amoxicillin trihydrate capsules is simple, inexpensive, easy to use and could be used in routine monitoring especially in the absence of high technology equipment. This study shows the needing for more market monitoring of all available brands of all drugs in the drug market of Gaza Strip-Palestine.