Stimulation of creatine kinase BB activity by 1α,25-dihydroxycholecalciferol and 24R,25-dihydroxycholecalciferol in rat tissues

Abstract

Vitamin D metabolites stimulate creatine kinase BB activity in organs of vitamin D-deficient rats. In epiphyses of long bones, creatine kinase BB activity increases 2.6-fold 24 h after injection of 24R,25-dihydroxycholecalciferol but not of 1α,25-dihydroxycholecalciferol. Contrarywise, 1α,25-dihydroxycholecalciferol, but not 24R,25-dihydroxycholecalciferol, increases creatine kinase BB activity in diaphyses and in kidney. Neither metabolite affects creatine kinase activity in duodenal mucosa.