An electrochemical synthesis of functionalized arylpyrimidines from 4-Amino-6-Chloropyrimidines and aryl halides

Abstract

A range of novel 4-amino-6-arylpyrimidines has been prepared under mild conditions by an electrochemical reductive cross-coupling between 4-amino-6-chloropyrimidines and functionalized aryl halides. The process, which employs a sacrificial iron anode in conjunction with a nickel(II) catalyst, allows the formation of coupling products in moderate to high yields. © 2011 by the authors; licensee MDPI, Basel, Switzerland.