A simple and efficient procedure for synthesis of symmetrical bis(4-amino-4H-1,2,4-triazole-5-thiols)

Abstract

A series of bis(1,2,4-triazole-3-thiols) 3a-d were prepared by condensation reactions of arylbis(carboxymethylthio)methanes 2a-d with thiocarbohydrazide. The starting diacids 2a-d were prepared by reactions of aromatic aldehydes 1a-d with thioglycolic acid. The structures of these newly synthesized compounds are characterized by elemental analysis, IR, and NMR spectroscopy.