A New Benzophenone Derivative from the Endophyte Shiraia sp. BYJB-1

Abstract

A new benzophenone derivative, shiraone A (1), along with seven known compounds, linchenxantone (2), 4-hydroxymellein (3), hypocrellin A (4), hypocrellin B (5), 9,11-dehydroergosterol peroxide (6), ergosteroal peroxide (7), and lactariolide I (8), were isolated from the cultures of Shiraia sp. BYJB-1, a fungus from the leaves of the medicinal plant Selaginella delicatula. The structures of these compounds were established via extensive spectroscopic techniques, including 1D/2D NMR, HRESIMS and through comparison with data reported in the literatures. In addition, the cytotoxic activities and antibacterial activities of compounds 1-8 were evaluated, and compounds 6 and 7 exhibited moderate cytotoxic activities against SMMC7721 cell line with IC50 values of 25.9 and 45.8 μM respectively.