Efficient synthesis of esters containing tertiary amine functionalities via active cyanomethyl ester intermediates

Abstract

Esters containing tertiary amine functionalities were successfully synthesized under mild conditions and in good yields, using a three-step process involving the activation of acids into their corresponding cyanomethyl esters, followed by transesterification with the alcohol counterparts, and subsequent scavenging of the excess of alcohol to facilitate purification. © 2009 Elsevier Ltd. All rights reserved.