SECONDARY METABOLITES FROM MICROMONOSPORA SP. (G044)

  • Tuan C
  • Huong D
  • Ngan T
  • et al.
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Abstract

In the course of our screening program, the EtOAc extract of a Micromonospora sp. (strain G044) from sponge Tethya aurantium of the sea of Côtô - Thanh Lân exhibited antimicrobial activity against Enterococcus faecalis, Bacillus cereus and Candida albicans. In this paper, we reported the isolation and structural elucidation of six secondary metabolites Cyclo-(Pro-Trp) (1), Cyclo-(Pro-Met) (2), Cyclo-(Pro-Val) (4), N-acetyltryptamine (3), uridine (5), and 2-phenylacetic acid (6) from the cultures broth of Micromonospora sp. (strain G044). The structures of 1 – 6 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compound 1 inhibited Escherichia coli with a MIC value of 128 µg/ml.

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Tuan, C. D., Huong, D. T. M., Ngan, T. B., Quyen, V. T., Minh, L. T. H., Brian, M., … Cuong, P. V. (2017). SECONDARY METABOLITES FROM MICROMONOSPORA SP. (G044). Vietnam Journal of Science and Technology, 55(3), 251. https://doi.org/10.15625/2525-2518/55/3/8641

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