Looking Beyond the Monoamine Hypothesis

Abstract

Milak et al. 11 have investigated the association between different psychopathological clusters of the Hamilton Depression Rating Scale (HDRS) and resting glucose metabolism using 18 fluoride-fluorodeoxyglucose ((18F)-FDG) PET. They found distinct correlations between three HDRS factors and regional glucose metabolism. The first factor, psychic depression, showed a positive correlation with metabolism in the basal ganglia, thalamus and cingulate cortex. The second factor, sleep disturbance, showed a positive correlation …