Computational evaluation and anti-inflammatory and analgesic activities of nebrodenside a isolated from dodonaea viscosa

Abstract

Nebrodenside A was isolated from the plant Dodonaea viscosa and its chemical structure was elucidated by spectroscopic methods. Molecular docking simulation predicted its strong ability to be tested as a potential anti-inflammatory compound. Carrageen-induced paw model and formalin test were utilized for the assessment of anti-inflammatory and analgesic potential. Nebrodenside A was found to be significantly active in reducing inflammation, when compared with diclofenac as a standard drug. Similarly, the compound also possesses substantial analgesic activity in the formalin-induced writhing test. Thus, nebrodenside A revealed a robust potential to be developed as a possible leading medicinal agent for better management of pain and inflammation.