28. Studies on Oxidized Starch Sulfates for Medical Purposes. III. Inhibition of the Proteolytic Action of Pepsin by Sulfates of Oxidized Starch and its Reduced Products

Abstract

The inhibitory effect of polysaccharide sulfates on the proteolytic action of pepsin is due to their sulfate group and is enhanced with the increasing sulfate group content. The effect of DP on the inhibitory activity is weaker than that of the sulfur content, but the minimum critical value is necessary for the appearance of inhibitory action. Inhibitory effect is influenced largely by DP, especially in samples with a small sulfur content, and slightly by samples with a large sulfur content. The inhibitory activity by polysaccharide sulfates is not correlated to their anticoagulant activity. © 1962, The Pharmaceutical Society of Japan. All rights reserved.