Synthesis and properties of diazirinyl organo-platinum compounds for manipulations of photoaffinity labeled components

Abstract

Synthesis of diazirinyl organo-platinum complexes, which specifically interact with purine base, characterization of photoreactivity and interaction between guanosine 5′-monophosphate (GMP) were examined. The results indicated that the diazirinyl organo-platinum complex was useful for manipulations of photoaffinity labeled components. © 2010 Pharmaceutical Society of Japan.