Protective effects of vitamin E and vitamin C on gentamicin-induced nephrotoxicity in sheep

Abstract

Gentamicin is a commonly used antibiotic medication and this is an aminoglycoside antibiotic, used to treat many types of bacterial infections, particularly those caused by gram-negative organisms. Gentamicin can also be highly nephrotoxic, particularly if multiple doses accumulate over a course of treatment or in dehydrated cases. The aim of this study was to investigate the protective role of vitamin E against Gentamicin-mduced nephrotoxicity in sheep. Eighteen healthy Ghezel sheep were randomly divided into three groups of control and treatments with vitamin C and E. All sheep of two groups were received 20 mg/kg/body wt. of Gentamicin every 8 h by intramuscular injection for 10 days. Treatment group were also receive 250 mg/kg/body wt. of vitamin E and C daily by intramuscular injection for 14 days. This study revealed that the GM-induced renal toxicity as measured by multiple functional, structural and enzymatic factors is significantly reduced by co-supplementation of vitamins C andE. The results of this study suggest the potential of antioxidant vitamins to protect against GM-induced nephrotoxicity. © Medwell Journals, 2012.