AKURASI PETANDA BIOKIMIA COMP DAN CTX-II SEBAGAI PREDIKTOR AWAL OSTEOARTRITIS GENU

Abstract

Abstrak Petanda biokimia COMP dan CTX-II sensitif untuk mendeteksi awal terjadinya osteoartriti s genu. Namun demikian, bila dilihat dari hasil penilaian citra digital radiografi genu menggunakan Kellgren-Lawrence (KL) grade, ternyata grading osteoartritis genu belum tentu sesuai dengan hasil pemeriksaan kadar COMP dan CTX-II. Jenis penelitian ini adalah cross-sectional dengan observasional analitik. Sebanyak 36 responden dipilih berdasarkan hasil citra digital radiografi genu proyeksi AP weight bearing kanan dan kiri dengan KL grade < 2. COMP diambil dari pembuluh darah vena perifer sebanyak 10 ml dan CTX-II diambil dari urin. Penentuan kadar COMP dan CTX-II menggunakan enzyme-linked immunosorbent assay (ELISA). Analisa data dilakukan dengan uji Receiver Operating Characteristic (ROC) dan uji Chi Square. Hasil penelitian menunjukkan tingkat akurasi kadar COMP terhadap osteoartritis genu; sensitifitas 96,30%, spesifisitas 33,33%, prediksi positif 81,25% dan prediksi negative 75% terhadap prevalensi OA 75%, serta terdapat hubungan yang signifikan (p = 0,041) dengan kekuatan hubungan kuat (0,778). Sedangkan tingkat akurasi kadar CTX-II terhadap osteoartritis genu; sensitifitas 59,26%, spesifisitas 77,78 %, prediksi positif 88.89% dan prediksi negative 38.89% terhadap prevalensi OA 75%, terdapat hubungan yang tidak signifikan (p = 0,121) dengan kekuatan hub ungan lemah (0,305). Petanda biokimia COMP lebih akurat dalam menentukan diagnosa osteoartritis genu dibandingkan petanda biokimia CTX-II. Abstract [COMP AND CTX-II BIOCHEMICAL MARKER ACCURACY AS A PREDICTOR OF OSTEOARTHRITIS GENU] Biochemical markers COMP and CTX-II sensitive to detect the onset of osteoarthritis genu. However, when viewed from the digital image radiographic assessment genu using Kellgren-Lawrence (KL) grade, was grading osteoarthritis genu not necessarily correspond with the results of the examination levels of COMP and CTX-II. The study was cross-sectional with analytical observation. A total of 36 respondents were selected based on the results of digital radiography image projection AP genu weight bearing right and left with KL grade <2 COMP taken from peripheral venous blood vessel 10 ml and CTX-II were taken from urine. Determination of COMP and CTX-II using enzyme-linked immunosorbent assay (ELISA). Data analysis was done with the test Receiver Operating Characteristic (ROC) and the Chi Square test. The results showed an accuracy rate against osteoarthritis genu COMP levels; a sensitivity of 96.30%, a specificity of 33.33%, 81.25% positive predictive and negative predictive of OA prevalence of 75% to 75%, and a significant correlation (p = 0.041) with the power of a strong relationship (0.778). While the level of accuracy levels of CTX-II against osteoarthritis genu; a sensitivity of 59.26%, a specificity of 77.78%, 88.89% positive predictive and negative predictive 38.89% in the prevalence of OA 75%, there is no significant relationship (p = 0.121) with the strength of weak ties (0,305). As a predictor of early osteoarthritis genu, the biochemical markers COMP proved more accurate in diagnosing osteoarthritis genu compared biochemical marker CTX-II.