Abstract
Two new cucurbitane-type triterpenes, 24-hydroperoxycucurbita-5,25-dien- 3β-ol (1) and 25-hydroperoxycucurbita-5,23-dien-3β-ol (2), were isolated from a MeOH extract of Citrullus lanatus seeds. Compounds 1 and 2 exhibited moderate cytotoxic activities with IC50 values of 33.4-52.4 μM against HL-60 (human leukemia), P388 (murine leukemia), and L1210 (murine leukemia) cells. Compound 1 showed melanogenesis inhibitory activity (melanin content 80.0%) with low cytotoxicity (cell viability 97.6%) at a low concentration (10 μM).
Author supplied keywords
Cite
CITATION STYLE
Kikuchi, T., Okada, R., Harada, Y., Ikushima, K., Yamakawa, T., Yamada, T., & Tanaka, R. (2013). Cucurbitane-type triterpenes from Citrullus lanatus (watermelon) seeds. Natural Product Communications, 8(10), 1367–1369. https://doi.org/10.1177/1934578x1300801006
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
