A (1-3)-β-D-glucan, grifolan (GRN), recovered from the peritoneal cavity after 1 d from i.p. injection contained a significant amount of anionic metabolite(s) having lower Mr than the parent GRN. In parallel with this observation, GRN induced peritoneal exudate cells exhibiting a higher level of oxidative burst than the non-stimulated, resident peritoneal cells. Chemical oxidation of GRN by active oxygen species such as (a) ascorbic acid-CuSO4, (b) hydrogen peroxide, (c) hydrogen peroxide-CuSO4, or (d) hypochlorous acid also produced anionic as well as lower Mr degradation products. Under these experimental conditions the structural changes were remarkable and in the order of a
CITATION STYLE
Nono, I., Ohno, N., Masuda, A., Oikawa, S., & Yadomae, T. (1991). Oxidative Degradation of an Antitumor (l-3)-β-D-Glucan, Grifolan. Journal of Pharmacobio-Dynamics, 14(1), 9–19. https://doi.org/10.1248/bpb1978.14.9
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