Oxidative Degradation of an Antitumor (l-3)-β-D-Glucan, Grifolan

35Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

A (1-3)-β-D-glucan, grifolan (GRN), recovered from the peritoneal cavity after 1 d from i.p. injection contained a significant amount of anionic metabolite(s) having lower Mr than the parent GRN. In parallel with this observation, GRN induced peritoneal exudate cells exhibiting a higher level of oxidative burst than the non-stimulated, resident peritoneal cells. Chemical oxidation of GRN by active oxygen species such as (a) ascorbic acid-CuSO4, (b) hydrogen peroxide, (c) hydrogen peroxide-CuSO4, or (d) hypochlorous acid also produced anionic as well as lower Mr degradation products. Under these experimental conditions the structural changes were remarkable and in the order of a

Cite

CITATION STYLE

APA

Nono, I., Ohno, N., Masuda, A., Oikawa, S., & Yadomae, T. (1991). Oxidative Degradation of an Antitumor (l-3)-β-D-Glucan, Grifolan. Journal of Pharmacobio-Dynamics, 14(1), 9–19. https://doi.org/10.1248/bpb1978.14.9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free