Inhibitory effect of four triterpenoids from trichilia connaroides on nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells

Abstract

Two new highly rearranged trichiliton-type limonoids (trichilitons G-H, 1-2), and two new cycloartane- type triterpenoids, 21-(E)-coumaroyloxy-5α- cycloart-24-ene-3,23-dione (3) and 21-(E)-feruloyloxy-5α- cycloart-24-ene-3,23-dione (4), were isolated from the stem and bark of Trichilia connaroides. These isolates were elucidated on the basis of detailed spectroscopic analysis, and inhibitory effect of these compounds on lipopolysaccharide-induced nitric oxide production in mouse macrophage RAW264.7 cells was evaluated. © 2013 The Pharmaceutical Society of Japan.