It is the time to think about a treat-to-target strategy for knee osteoarthritis

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Osteoarthritis (OA) is a rheumatic disease that affects the well-being of the patient, compromises physical and mental function, and affects other quality of life aspects. In the literature, several evidence-based guidelines and recommendations for the management of knee osteoarthritis (KOA) are available. These recommendations list the different therapeutic options rather than addressing a hierarchy between the treatments and defining the real target. Therefore, a question arises: are patients and physicians satisfied with the current management of KOA? Actually, the answer may be negative, thus suggesting a change in our therapeutic strategies. In this article, we address this challenge by suggesting that it is time to develop a “treat to target strategy” for KOA.




Migliore, A., Gigliucci, G., Petrella, R. J., Bannuru, R. R., Chevalier, X., Maheu, E., … Matucci Cerinc, M. (2019). It is the time to think about a treat-to-target strategy for knee osteoarthritis. Therapeutics and Clinical Risk Management, 15, 1479–1482.

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