Friedelin: A bacterial resistance modulator from Paulinia Pinnata L.

Abstract

As part of the project to identify plant natural products which modulate bacterial multidrug resistance (MDR), bioassay-guided isolation of the methanol extract of Paullinia pinnata L. roots yielded four known compounds namely friedelin, β-sitosterol, β-sitosterol acetate and β-sitosterol D-glucoside. The structures were established by spectroscopic methods and comparison with published data. These compounds were tested for in vitro antibacterial and resistance modifying activities against