Molecular and immunological characteristics of Candida Secreted Aspartyl Proteinase 5

Abstract

Candida sp. is the most common of yeasts causes fungal infections in human. One virulence factor of Candida sp. is the Secreted Aspartyl Proteinase (SAP) 5. However, the molecular and immunological characteristics of the Candida Secreted Aspartyl Proteinase 5 is still limited known. To study the molecular and immunological characteristics of the Candida Secreted Aspartyl Proteinase 5, all complete coding sequences of Candida Secreted Aspartyl Proteinase 5 deposited in GenBank were retrieved and subjected to bioinformatic analysis. The sequences alignment was used to predict the evolutionary relationships among various Candida sp. based on the Secreted Aspartyl Proteinase 5 gene and to find out any possible genomic and proteomic variations. The molecular weight (Mw), signal peptide, protein charge, antigenicity, hydrophobicity, estimated half-life, and secondary structure of the predicted proteins also had been discussed. The results from this study would contribute information of molecular and immunological characteristics of the Candida Secreted Aspartyl Proteinase 5.