Monitoring for myelopathic progression with multiparametric quantitative MRI

61Citations
Citations of this article
58Readers
Mendeley users who have this article in their library.

Abstract

Background Patients with mild degenerative cervical myelopathy (DCM) are often managed non-operatively, and surgery is recommended if neurological progression occurs. However, detection of progression is often subjective. Quantitative MRI (qMRI) directly measures spinal cord (SC) tissue changes, detecting axonal injury, demyelination, and atrophy. This longitudinal study compared multiparametric qMRI with clinical measures of progression in non-operative DCM patients. Methods 26 DCM patients were followed. Clinical data included modified Japanese Orthopedic Association (mJOA) and additional assessments. 3T qMRI data included cross sectional area, diffusion fractional anisotropy, magnetization transfer ratio, and T2*-weighted white/grey matter signal ratio, extracted from the compressed SC and above/below. Progression was defined as 1) patients’ subjective impression, 2) 2-point mJOA decrease, 3) 3 clinical measures worsening 5%, 4) increased compression on MRI, or 5) 1 of 10 qMRI measures or composite score worsening (p < 0.004, corrected). Results Follow-up (13.5 ± 4.9 months) included mJOA in all 26 patients, MRI in 25, and clinical/qMRI in 22. 42.3% reported subjective worsening, compared with mJOA (11.5%), MRI (20%), comprehensive assessments (54.6%), and qMRI (68.2%). Relative to subjective worsening, qMRI showed 100% sensitivity and 53.3% specificity compared with comprehensive assessments (75%, 60%), mJOA (27.3%, 100%), and MRI (18.2%, 81.3%). A decision-making algorithm incorporating qMRI identified progression and recommended surgery for 11 subjects (42.3%). Conclusions Quantitative MRI shows high sensitivity to detect myelopathic progression. Our results suggest that neuroplasticity and behavioural adaptation may mask progressive SC tissue injury. qMRI appears to be a useful method to confirm subtle myelopathic progression in individual patients, representing an advance toward clinical translation of qMRI.

Cite

CITATION STYLE

APA

Martin, A. R., De Leener, B., Cohen-Adad, J., Kalsi-Ryan, S., Cadotte, D. W., Wilson, J. R., … Fehlings, M. G. (2018). Monitoring for myelopathic progression with multiparametric quantitative MRI. PLoS ONE, 13(4). https://doi.org/10.1371/journal.pone.0195733

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free