Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments

13Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Acral melanoma (AM) exhibits a high incidence in Asian patients with melanoma, and it is not well treated with immunotherapy. However, little attention has been paid to the characteristics of the immune microenvironment in AM. Therefore, in this study, we collected clinical samples from Chinese patients with AM and conducted single-cell RNA sequencing to analyze the heterogeneity of its tumour microenvironments (TMEs) and the molecular regulatory network. Our analysis revealed that genes, such as TWIST1, EREG, TNFRSF9, and CTGF could drive the deregulation of various TME components. The molecular interaction relationships between TME cells, such as MIF–CD44 and TNFSF9–TNFRSF9, might be an attractive target for developing novel immunotherapeutic agents.

Cite

CITATION STYLE

APA

He, Z., Xin, Z., Yang, Q., Wang, C., Li, M., Rao, W., … Zhao, H. (2022). Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments. ELife, 11. https://doi.org/10.7554/ELIFE.78616

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free