Formulation and Evaluation of Gastro-retentive Floating tablets of Terbinafine

Abstract

Delivery of drugs at a specific region in gastrointestinal tract, the so called absorption window needs the development of gastro retentive dosage forms. The attempts to develop gastro retentive drug delivery systems may be largely divided into two classes: those that rely on the natural physiology of the gastrointestinal tract and those that are designed to overcome it. Approaches such as size or floatation, which rely on delayed emptying from the stomach, depend on the normal physiological duration of the fed state of 4-8 hr, following a meal and rather reproducible transit time through the small intestine. The main objective of this work was to investigate the possibility of improving the solubility and dissolution rate of Terbinafine by preparing Gastro retentive Floating Tablets. Being a weak acid, the drug is well absorbed from the upper portion of duodenum. Therefore, a floating system is expected to produce a prolonged release of the drug.