Long-term immunosuppresion and drug interactions

Abstract

1. Early patient and graft survival are excellent after liver transplantation. 2. The focus must be on reducing toxicity associated with long-term immunosuppression. 3. Available new drugs offer the potential to reduce toxicity by combination therapy or replacement of toxic agents. 4. Individual patient immunosuppressive protocols should be developed. 5. Drug interactions are common and the source of significant morbidity.