Severe hypotony and filtering bleb leak after intravitreal injection of ranibizumab

Abstract

We report a case of a patient with age-related macular degeneration, who had undergone trabeculectomy nine years earlier, and developed severe hypotony and bleb leak after treatment with intravitreal injections of ranibizumab. Although the incident is rare, in patients with longstanding fi ltering blebs, who need treatment with antivascular endothelial growth factors, close follow-up may be advocated, since the occurrence of bleb rupture could lead to permanent vision loss. © 2009 Georgalas et al, publisher and licensee Dove Medical Press Ltd.