suplementos de proteÍna de suero y soya cambia la composiciÓn corporal en los pacientes con enfermedad de crohn sometidos con azatioprina y anti-TNF-alfa terapias

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Abstract

Background: Crohn’s disease (CD) is a chronic transmural inflammation of the gastrointestinal tract of unknown cause. Malnutrition associated with active CD has been reduced although obesity has increased. Dietary strategies such as those with high-protein have been proposed to reduce body fat. This study compares the effects of two supplements on the nutritional status of CD patients. Materials and Methods: 68 CD patients were randomized in two groups: whey protein group (WP) and soy protein group (SP). Using bioimpedance analysis, anthropometry and albumin and pre-albumin dosages the nutritional status was measured before starting the intervention and after 8 and 16 weeks. The disease activity was determined by Crohn’s Disease Activity Index and serum C-reactive protein dosage and dietary intake by 24h dietary recalls. Results: Forty-one patients concluded the study and both supplements changed body composition similarly. Triceps skin fold thickness (p< 0.001) and body fat percentage (p=0.001) decreased, whereas mid-arm muscle circumference (p=0.004), corrected arm muscle area (p=0.005) and body lean percentage (p=0.001) increased. Conclusions: For Crohn’s disease patients undergoing anti TNF-alpha and azatioprine therapies, supplementation with whey and soy proteins changes body composition through reduction of body fat and thus contributes to control inflammation.

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Machado, J. F., Oya, V., Coy, C. S. R., Morcillo, A. M., Severino, S. D., Wu, C., … dos Santos Vilela, M. M. (2015). suplementos de proteÍna de suero y soya cambia la composiciÓn corporal en los pacientes con enfermedad de crohn sometidos con azatioprina y anti-TNF-alfa terapias. Nutricion Hospitalaria, 31(4), 1603–1610. https://doi.org/10.3305/nh.2015.31.4.8362

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