Design and Development of Dual Drug Loaded Niosomes Containing Amoxicillin and Clavulanic acid

Abstract

Niosomes formulation for the fixed dose combinations of amoxicillin-clavulanic acid were prepared using Span 60 and cholesterol by the ether injection method. Span 60 and cholesterol were added in various molar ratios to affect the vesicle membrane rigidity. Drugs combinations of amoxicillin-clavulanic acid entrapped in the bilayer of niosomes were quantified and the entrapment efficiency was found to be reaching up to 76%. The size and size distribution of niosomes were determined on light microscopy and transmission electron microscopy. The accelerated stability testing was used to predict the stability of the formulations. The test revealed changes in the characteristics of the liposomes. The in-vitro antibacterial assay of amoxicillin-clavulanic acid, revealed that niosomes formulations have stronger inhibitory activity.