Stem cell transplant and the potential role of CAR-T cells in multiple myeloma

Abstract

Multiple myeloma is still an incurable cancer notwithstanding the myriads of chemo-and immunotherapies, There are more than 20,000 cases of MM diagnosed per year in the US. Bone marrow transplant is still considered the cornerstone for MM therapy, at least for now. The evident need is to revisit the conventional treatment approaches to cellular therapy, such as auto-and/or allogeneic hematopoietic stem cell transplantation (HCT), and develop the new options, like CAR-T cells. This review article will present and discuss different approaches to modern treatment of MM, by summarizing the results of clinical studies, raising feasibility and efficiency questions, and answering some of them which have been already resolved in numerous trials performed with CAR-T cells.