New Frontiers on ER Stress Modulation: Are TRP Channels the Leading Actors?

7Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

The endoplasmic reticulum (ER) is a dynamic structure, playing multiple roles including calcium storage, protein synthesis and lipid metabolism. During cellular stress, variations in ER homeostasis and its functioning occur. This condition is referred as ER stress and generates a cascade of signaling events termed unfolded protein response (UPR), activated as adaptative response to mitigate the ER stress condition. In this regard, calcium levels play a pivotal role in ER homeostasis and therefore in cell fate regulation since calcium signaling is implicated in a plethora of physiological processes, but also in disease conditions such as neurodegeneration, cancer and metabolic disorders. A large body of emerging evidence highlighted the functional role of TRP channels and their ability to promote cell survival or death depending on endoplasmic reticulum stress resolution, making them an attractive target. Thus, in this review we focused on the TRP channels’ correlation to UPR-mediated ER stress in disease pathogenesis, providing an overview of their implication in the activation of this cellular response.

Cite

CITATION STYLE

APA

Vestuto, V., Di Sarno, V., Musella, S., Di Dona, G., Moltedo, O., Gomez-Monterrey, I. M., … Ciaglia, T. (2023, January 1). New Frontiers on ER Stress Modulation: Are TRP Channels the Leading Actors? International Journal of Molecular Sciences. MDPI. https://doi.org/10.3390/ijms24010185

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free