Brain connectivity changes associated with episodic recollection decline in aging: A review of fMRI studies

Abstract

With advancing age, individuals experience a gradual decline in recollection, the ability to retrieve personal experiences accompanied by details, such as temporal and spatial contextual information. Numerous studies have identified several brain regions that exhibit age-related activation differences during recollection tasks. More recently, an increasing number of studies have provided evidence regarding how brain connectivity among the regions supporting recollection contributes to the explanation of recollection deficits in aging. However, brain connectivity evidence has not been examined jointly to provide an integrative view of how these new findings have improved our knowledge of the neurofunctional changes underlying the recollection deficits associated with aging. Therefore, the aim of the present study was to examine functional magnetic resonance imaging (fMRI) studies that employed one of the numerous methods available for analyzing brain connectivity in older adults. Only studies that applied connectivity analysis to data recorded during episodic recollection tasks, either during encoding or retrieval, were assessed. First, the different brain connectivity analysis methods and the information conveyed were briefly described. Then, the brain connectivity findings from the different studies were described and discussed to provide an integrative point of view of how these findings explain the decline in recollection associated with aging. The studies reviewed provide evidence that the hippocampus consistently decreased its connectivity with the parahippocampal gyrus and the posterior cingulate cortex, essential regions of the recollection network, in older adults relative to young adults. In addition, older adults exhibited increased connectivity between the hippocampus and several widespread regions compared to young adults. The increased connectivity was interpreted as brain intensification recourse to overcome recollection decay. Additionally, suggestions for future research in the field are outlined.