Neuroprotective kaurane diterpenes from Fritillaria ebeiensis

Abstract

The new kaurane diterpene, ent-3β-butanoyloxykaur- 15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP +-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.